Concepedia

MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport

Fan Zhang, Stacy L. Throm, Laura Lea Murley, Laura A. Miller, Douglas S. Zatechka, R. Kiplin Guy, R. Moffatt Kennedy, Clinton F. Stewart

Biochemical Pharmacology · 2011 · 26 citations · 25 references

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25

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

, , +15

A multidrug resistance transporter from human MCF-7 breast cancer cells

L. Austin Doyle, Weidong Yang, Lynne V. Abruzzo et al. · Proceedings of the National Academy of Sciences · 1998 · 2.3K citations

, , +16

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy

Christian Tovar, James Rosinski, Zoran Filipovic et al. · Proceedings of the National Academy of Sciences · 2006 · 703 citations · Full text

, , +17

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

Balázs Sarkadi, Elmer M. Price, R. C. Boucher et al. · Journal of Biological Chemistry · 1992 · 632 citations · Full text

, , +7

Inactivation of the p53 pathway in retinoblastoma

Nikia A. Laurie, Stacy L. Donovan, Chie‐Schin Shih et al. · Nature · 2006 · 587 citations

, , +12