Concepedia

The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist, in varying degrees of renal impairment

Neeraj Dhaun, Vanessa Melville, William G. Kramer, Fiona Stavros, Terrance Coyne, Suzanne K. Swan, Jane Goddard, David J. Webb

British Journal of Clinical Pharmacology · 2007 · 16 citations · 9 references

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Abstract

After a single 100-mg oral dose of sitaxsentan there were no differences in its pharmacokinetics among subjects with normal or impaired renal function.

References

9

Prediction of Creatinine Clearance from Serum Creatinine

Donald W. Cockcroft, Henry Gault · Nephron · 1976 · 15.3K citations

Report of the committee on the genetic constitution of autosomes other than chromosomes 1, 2, and 6

F.H. Ruddle, P. Meera Khan · Cytogenetic and Genome Research · 1976 · 851 citations

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Clearance of Circulating Endothelin-1 by ETB Receptors in Rats

Takahiro Fukuroda, Tatsuya Fujikawa, Satoshi Ozaki et al. · Biochemical and Biophysical Research Communications · 1994 · 624 citations

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Contribution of endogenous generation of endothelin-1 to basal vascular tone

William G. Haynes · The Lancet · 1994 · 589 citations

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Discovery of TBC11251, a Potent, Long Acting, Orally Active Endothelin Receptor-A Selective Antagonist

Chengde Wu, Ming Fai Chan, Fiona Stavros et al. · Journal of Medicinal Chemistry · 1997 · 124 citations · Full text