Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz, +1

Nature

Tumor BiologyMedicineRapid DegradationProtein DegradationTumor Suppressor +4

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Taichi Hara, Kenji Nakamura, Makoto Matsui, +8

Nature

Neural CellsCell AutophagyNeurodegenerative DiseasesMitophagyAutophagy +10

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Masaaki Komatsu, Satoshi Waguri, Tomoki Chiba, +8

Nature

Cell AutophagyNeurodegenerative DiseasesMitophagyAutophagyCell Death +10

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden

Nature

Tumor BiologyTumor SuppressorMedicineCell BiologyCancer Research +1

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Geir Bjørkøy, Trond Lamark, Andreas Brech, +5

The Journal of Cell Biology

β-catenin is a target for the ubiquitin–proteasome pathway

Hermann Aberle, Andreas Bauer, Jörg Stappert, +2

The EMBO Journal

Protein FunctionMolecular RegulationMedicineProteasomeProtein Degradation +4

Impairment of starvation-induced and constitutive autophagy in <i>Atg7</i> -deficient mice

Masaaki Komatsu, Satoshi Waguri, Takashi Ueno, +10

The Journal of Cell Biology

Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

Masaaki Komatsu, Satoshi Waguri, Masato Koike, +22

Cell

Cell AutophagyMitophagyDevelopmental BiologyAutophagy-deficient MiceAutophagy +8

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

Julie L. Webb, Brinda Ravikumar, Jane T. Atkins, +2

Journal of Biological Chemistry

MitophagyProteasomeMolecular BiologyCell DeathCell Autophagy +14

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

Noboru Mizushima, Akitsugu Yamamoto, Masahiko Hatano, +6

The Journal of Cell Biology