Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

Tumor Biology, Medicine, Rapid Degradation +6

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Taichi Hara, Kenji Nakamura, Makoto Matsui et al. · Nature · 2006 · 3.8K citations

Neural Cells, Cell Autophagy, Neurodegenerative Diseases +12

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Masaaki Komatsu, Satoshi Waguri, Tomoki Chiba et al. · Nature · 2006 · 3.4K citations

Cell Autophagy, Neurodegenerative Diseases, Mitophagy +12

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

Tumor Biology, Tumor Suppressor, Medicine +3

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Geir Bjørkøy, Trond Lamark, Andreas Brech et al. · The Journal of Cell Biology · 2005 · 3.2K citations · Full text