Association between genetic variants in the IRGM gene and tuberculosis in a Korean population

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

Maximiliano G. Gutiérrez, Sharon Master, Sudha Singh et al. · Cell · 2004 · 2.2K citations · Full text

Life Sciences, Immunology, Microbiology +16

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Miles Parkes, Jeffrey C. Barrett, Natalie J. Prescott et al. · Nature Genetics · 2007 · 1.2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +15

Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

Sudha Singh, Alexander S. Davis, Gregory A. Taylor et al. · Science · 2006 · 906 citations

Life Sciences, Infectious Diseases, Microbiology +17

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

Steven A. McCarroll, Alan Huett, Petric Kuballa et al. · Nature Genetics · 2008 · 661 citations · Full text

Medicine, Genetics, Molecular Genetics +12

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

Patrick Brest, Pierre Lapaquette, Mouloud Souidi et al. · Nature Genetics · 2011 · 561 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17