Concepedia

Gene transfer into guinea pig cochlea using adeno‐associated virus vectors

Masaya Konishi, Kohei Kawamoto, Masahiko Izumikawa, Hiromichi Kuriyama, Toshio Yamashita

The Journal of Gene Medicine · 2008 · 95 citations · 50 references

DOI

Abstract

Our results indicate that AAV vector can be safely applied to the inner ear and AAV-2/2 offers a good tool for transferring transgenes into sensory cells of the inner ear efficiently without toxicity.

References

50

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

Guangping Gao, Mauricio R. Alvira, Lili Wang et al. · Proceedings of the National Academy of Sciences · 2002 · 1.5K citations · Full text

Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions

Candace Summerford, R. Jude Samulski · Journal of Virology · 1998 · 1.4K citations · Full text

Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity

Joseph E. Rabinowitz, Fabienne Rolling, Chengwen Li et al. · Journal of Virology · 2002 · 743 citations · Full text

Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System

Corinna Bürger, Oleg S. Gorbatyuk, Margaret J. Velardo et al. · Molecular Therapy · 2004 · 732 citations · Full text

Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals

Masahiko Izumikawa, Ryosei Minoda, Kohei Kawamoto et al. · Nature Medicine · 2005 · 726 citations

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