Concepedia

Bax and Bcl-2 protein expression following radiation therapy versus radiation plus thermoradiotherapy in stage IIIB cervical carcinoma

Yoko Harima, Kenji Nagata, K Harima, Atsutoshi Oka, Valentina V. Ostapenko, Nobuaki Shikata, Takeo Ohnishi, Yoshimasa Tanaka

Cancer · 2000 · 59 citations · 29 references

DOI

Abstract

TRT was found to result in better treatment responses than RT for patients with Stage IIIB cervical carcinoma. An additive or synergistic antitumor effect of TRT is likely to occur through induction of apoptosis involving one of the bax pathways.

References

29

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Zoltán N. Oltval, Curt Milliman, Stanley J. Korsmeyer · Cell · 1993 · 6K citations

Bcl-2 Heterodimerizes, Cell Regulation, Apoptosis +6

Participation of p53 protein in the cellular response to DNA damage.

Michael B. Kastan, Onyinye Onyekwere, D Sidransky et al. · PubMed · 1991 · 3.8K citations

Dna Damage, Chemoprevention Strategy, Apoptosis +17

p53 is required for radiation-induced apoptosis in mouse thymocytes

Scott W. Lowe, Earlene M. Schmitt, Sallie W. Smith et al. · Nature · 1993 · 2.9K citations

Radiation-induced Apoptosis, Radiation Effect, Apoptosis +4

<i>p53</i> Status and the Efficacy of Cancer Therapy in Vivo

Scott W. Lowe, Stephan Bodis, Andrea I. McClatchey et al. · Science · 1994 · 1.5K citations

Cancer Therapy, P53 Status, Apoptosis +17

bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis.

Frank A. Sinicrope, San Bao Ruan, Karen R. Cleary et al. · PubMed · 1995 · 581 citations

Tumor Biology, Oncology, Spontaneous Apoptosis +13