Concepedia

Serum IL10 and circulating CD4<sup>+</sup>CD25<sup>high</sup> regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma

O Alhamarneh, Frank Agada, Leigh A. Madden, Nicholas D. Stafford, John Greenman

Head & Neck · 2010 · 47 citations · 37 references

DOIFull text

Open access

Abstract

IL10 is a potential independent factor in predicting a poor clinical outcome in newly presenting tumors of laryngeal and pharyngeal origin. The role of circulating Treg-cells as predictors of clinical outcome requires further investigation.

References

37

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Autocrine Production of IL-10 Mediates Defective IL-12 Production and NF-κB Activation in Tumor-Associated Macrophages

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