Serum IL10 and circulating CD4<sup>+</sup>CD25<sup>high</sup> regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma

Abstract

IL10 is a potential independent factor in predicting a poor clinical outcome in newly presenting tumors of laryngeal and pharyngeal origin. The role of circulating Treg-cells as predictors of clinical outcome requires further investigation.

References

Page 1

	Year	Citations
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. Timothy R. Mosmann, Holly Cherwinski, M W Bond, The Journal of Immunology Adaptive Immune SystemT-regulatory CellCellular ImmunologyImmunologyAntigen Processing	1986	7.5K
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival Tyler J. Curiel, George Coukos, Linhua Zou, Nature Medicine Cancer ImmunosurveillanceSpecific RecruitmentT-regulatory CellImmune RegulationImmunology	2004	5K
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells David Fiorentino, Albert Zlotnik, Paulo Vieira, The Journal of Immunology	1991	1.9K
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. Annalisa D’Andrea, Miguel Aste-Amézaga, Nicholas M. Valiante, The Journal of Experimental Medicine ImmunologyImmune RegulationNk CellsImmunologic MechanismInnate Immunity	1993	1.4K
Autocrine Production of IL-10 Mediates Defective IL-12 Production and NF-κB Activation in Tumor-Associated Macrophages Antonio Sica, Alessandra Saccani, Barbara Bottazzi, The Journal of Immunology	2000	412
<i>In vivo</i> dynamics of antigen-specific regulatory T cells not predicted from behavior <i>in vitro</i> Ludger Klein, Khashayarsha Khazaie, Harald von Boehmer Proceedings of the National Academy of Sciences	2003	373
Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3+ Regulatory T Cells Sylvain Ladoire, Laurent Arnould, Lionel Apétoh, Clinical Cancer Research	2008	303
CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers Koji Kono, Hiromichi Kawaida, Akihiro Takahashi, Cancer Immunology Immunotherapy Cancer ImmunosurveillanceEsophageal CancerMedicineT-regulatory CellImmunology	2005	286
The Frequency and Suppressor Function of CD4+CD25highFoxp3+ T Cells in the Circulation of Patients with Squamous Cell Carcinoma of the Head and Neck Laura Strauss, Christoph Bergmann, William E. Gooding, Clinical Cancer Research	2007	277
Cutting Edge: Induction of B7-H4 on APCs through IL-10: Novel Suppressive Mode for Regulatory T Cells Ilona Kryczek, Shuang Wei, Linhua Zou, The Journal of Immunology	2006	276

Page 1