Benzopyrenomycin, a Cytotoxic Bacterial Polyketide Metabolite with a Benzo[ <i>a</i> ]pyrene‐Type Carbocyclic Ring System

Abstract

A natural benzopyren: The title compound 1 was discovered by chemical metabolite profiling of a large-scale fermentation of Streptomyces lavendulae. Biological evaluation of the peri-fused pentacyclic compound revealed antitumor activity against several cell lines. The co-occurrence of an angucyclic polyketide with an identical ring-substitution pattern suggests that 1 is biosynthesized from an angular decaketide and a C3 building block.