Differential Regulation of Macropinocytosis by Abi1/Hssh3bp1 Isoforms

Abstract

Based on these observations, we postulate that Abi1 isoforms differentially regulate macropinocytosis as a consequence of their different relative affinities for activated Rac1 in Wave 2 complex. These findings also raise the possibility that isoform-specific roles occur in other Abi1 functions.