Sigma-1 receptor antagonism as opioid adjuvant strategy: Enhancement of opioid antinociception without increasing adverse effects

μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

Laura Bohn, Raul R. Gainetdinov, Fang‐Tsyr Lin et al. · Nature · 2000 · 916 citations

Medicine, Neuroscience, Pharmacology +14

Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.

S K Sharma, Werner A. Klee, Marshall W. Nirenberg · Proceedings of the National Academy of Sciences · 1975 · 669 citations · Full text

Medicine, Neuroscience, Pharmacology +17

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

Tsung‐Ping Su, Teruo Hayashi, Tangui Maurice et al. · Trends in Pharmacological Sciences · 2010 · 461 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Adolfo Saiardi, Olga Valverde, Tarek A. Samad et al. · Nature · 1997 · 440 citations

Medicine, Neurobiology, Neuroscience +14

Role of different brain structures in the expression of the physical morphine withdrawal syndrome.

Rafaël Maldonado, Luis Stinus, Lisa Gold et al. · Journal of Pharmacology and Experimental Therapeutics · 1992 · 389 citations

Medicine, Neuroscience, Pharmacology +17