Concepedia

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression

Shom Goel, Nisha Gupta, Brian P. Walcott, Matija Snuderl, Cristina T. Kesler, Nathaniel D. Kirkpatrick, Takahiro Heishi, Yuhui Huang, John D. Martin, Eleanor I Ager,

JNCI Journal of the National Cancer Institute · 2013 · 119 citations · 35 references

DOIFull text

Open access

Abstract

Our results demonstrate that pharmacological VE-PTP inhibition can normalize the structure and function of tumor vessels through Tie-2 activation, which delays tumor growth, slows metastatic progression, and enhances response to concomitant cytotoxic treatments.

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