SC-54684A: An Orally Active Inhibitor of Platelet Aggregation

Abstract

SC-54684A, an orally active antiplatelet drug now in clinical trial, is shown to be a potent, specific fibrinogen binding inhibitor that blocks platelet aggregation to a wide variety of known stimuli and has good bioavailability in animals.

References

Page 1

	Year	Citations
Order Restricted Statistical Inference. Thomas J. Santner, Tim Robertson, F. T. Wright, Journal of the American Statistical Association Estimation StatisticStatistical FoundationNormal Means CaseRegression AnalysisStatistical Inference	1990	1.6K
Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets J. Bryan Smith, A.L. Willis Nature New Biology InflammationThrombosisThrombopoiesisHuman PlateletsBlood Platelet	1971	1.5K
Platelet Membrane Glycoprotein IIb/IIIa: Member of a Family of Arg-Gly-Asp—Specific Adhesion Receptors Robert Pytela, Michael D. Pierschbacher, Mark H. Ginsberg, Science Cell AdhesionGlycobiologyMolecular BiologyCytoskeletonCellular Physiology	1986	934
Human platelets possess an inducible and saturable receptor specific for fibrinogen. G.A. Marguerie, EF Plow, T S Edgington Journal of Biological Chemistry Platelet-rich FibrinThrombosisPlatelet BiologyEngineeringBlood Platelet	1979	711
The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets. E F Plow, Michael D. Pierschbacher, Erkki Ruoslahti, Proceedings of the National Academy of Sciences Cell AdhesionImmunologyGlycobiologyPlatelet AggregationThrombosis	1985	590
Differential sensitivity of erythrocyte-rich and platelet-rich arterial thrombi to lysis with recombinant tissue-type plasminogen activator. A possible explanation for resistance to coronary thrombolysis. Ik–Kyung Jang, Herman K. Gold, Andrew A. Ziskind, Circulation Platelet-rich Arterial ThrombiBiomedical EngineeringAcute Myocardial InfarctionThrombosisHematology	1989	554
Novel purification of vitronectin from human plasma by heparin affinity chromatography. Takemi Yatohgo, Masako Izumi, Heihachiro Kashiwagi, Cell Structure and Function ImmunologyGlycobiologyGlycoprotein VitronectinCell CultureImmunotherapy	1988	515
The bleeding time does not predict surgical bleeding [see comments] SE Lind Blood Bleeding TimePatient SafetyVascular SurgeryHemostasisSurgery	1991	350
Increased surface expression of the membrane glycoprotein IIb/IIIa complex induced by platelet activation. Relationship to the binding of fibrinogen and platelet aggregation K Niiya, E Hodson, Rossella Bader, Blood	1987	263
[27] Arginine-glycine-aspartic acid adhesion receptors Robert Pytela, Michael D. Pierschbacher, Scott Argraves, Methods in enzymology on CD-ROM/Methods in enzymology Molecular PharmacologyMolecular PhysiologyMedicineCell AdhesionGlycobiology	1987	262

Page 1