Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Inge Grundke‐Iqbal, Khurshid Iqbal, Y C Tung et al. · Proceedings of the National Academy of Sciences · 1986 · 3.6K citations · Full text

Molecular Biology, Cytoskeleton, Microtubule-associated Protein Tau +19

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

Heather P. Harding, Yuhong Zhang, David Ron · Nature · 1999 · 3.2K citations

Protein Function, Signal Transduction, Protein Folding +6

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

Toshiyuki Nakagawa, Hong Zhu, Nobuhiro Morishima et al. · Nature · 2000 · 3.2K citations

Apoptosis, Cell Death, Degenerative Pathology +5

ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

Jingshi Shen, Xi Chen, Linda M. Hendershot et al. · Developmental Cell · 2002 · 1.4K citations · Full text

Protein Function, Signal Transduction, Golgi Localization Signals +12

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

Virginia M.‐Y. Lee, Brian J. Balin, László Ötvös et al. · Science · 1991 · 1.4K citations