Retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for hepatocellular carcinoma

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

John M. Chirgwin, Alan Przybyla, Raymond J. MacDonald et al. · Biochemistry · 1979 · 22.2K citations

Life Sciences, Biochemistry, Molecular Biology +9

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine

Gertrude B. Elion, Phillip A. Furman, James A. Fyfe et al. · Proceedings of the National Academy of Sciences · 1977 · 1.6K citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +13

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

Frederick L. Moolten · PubMed · 1986 · 972 citations

Medicine, Genetics, Oncology +16

In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.

Zvi Ram, Kenneth W. Culver, Stuart Walbridge et al. · PubMed · 1993 · 437 citations

Medicine, Oncology, Pharmacology +17

Gene Therapy for the Treatment of Brain Tumors Using Intra-Tumoral Transduction with the Thymidine Kinase Gene and Intravenous Ganciclovir. National Institutes of Health

Edward H. Oldfield, Zvi Ram, Kenneth W. Culver et al. · Human Gene Therapy · 1993 · 417 citations

Medicine, Molecular Medicine, Oncology +16