High Prion and PrPSc Levels but Delayed Onset of Disease in Scrapie-Inoculated Mice Heterozygous for a Disrupted PrP Gene

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251K citations

Protein Assembly, Natural Sciences, Structural Proteins +8

Novel Proteinaceous Infectious Particles Cause Scrapie

Stanley B. Prusiner · Science · 1982 · 5.1K citations

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

K M Pan, M. A. Baldwin, Jack Nguyen et al. · Proceedings of the National Academy of Sciences · 1993 · 2.3K citations · Full text

Prpsc Synthesis, Protein Chemistry, Protein Secretion +15

Mice devoid of PrP are resistant to scrapie

Hansruedi Büeler, Adriano Aguzzi, Andreas W. Sailer et al. · Cell · 1993 · 2.1K citations · Full text

Biology, Knockout Mouse, Mice Devoid +4

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

Hansruedi Büeler, Marek Fischer, Yolande Lang et al. · Nature · 1992 · 1.6K citations · Full text

Neuroregeneration, Developmental Biology, Normal Development +10