Concepedia

Inhibition of capsaicin‐induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK‐0974)

Simon Sinclair, Stefanie A. Kane, Bart Van der Schueren, Alan Xiao, K Willson, Janet Boyle, Inge De Lepeleire, Yang Xu, Lisa Hickey, William S. Denney,

British Journal of Clinical Pharmacology · 2009 · 85 citations · 27 references

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Abstract

Telcagepant inhibits the increases in DBF induced by the topical application of capsaicin on the human forearm. This experimental medicine model may have utility to assist in dose selection for the development of CGRP receptor antagonists.

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