Reduced endothelial secretion and plasma levels of transforming growth factor-β1 in patients with hereditary hemorrhagic telangiectasia type 1 - Concepedia

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Publication | Open Access

Reduced endothelial secretion and plasma levels of transforming growth factor-β1 in patients with hereditary hemorrhagic telangiectasia type 1

DOI Full Paper Access

43

Citations

29

References

2005

Year

Michelle Letarte, Merry‐Lynn McDonald, Chun Li, Kirishanthy Kathirkamathamby, Santiago Vera, Satish Kumar

Cardiovascular Research

Abstract

Decreased plasma TGF-beta1 levels in HHT1 patients correlate with reduced production by endothelial cells. The lower endoglin expression in these cells may alter the regulation of TGF-beta1 via Smad-independent pathways.

References

	Year	Citations
Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome) Claire L. Shovlin, Alan E. Guttmacher, Elisabetta Buscarini, American Journal of Medical Genetics	2000	1.7K
Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1 Kimberly A. McAllister, K.M. Grogg, David W. Johnson, Nature Genetics Endothelial Cell PathobiologyVascular DiseaseDevelopmental BiologyAngiogenesisEndothelial Cells	1994	1.5K
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4 Akihiro Nakao The EMBO Journal Signal TransductionMolecular PhysiologyTgf-beta Receptor-mediated SignallingSignaling PathwayMedicine	1997	1.1K
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response Gillian S. Ashcroft, Xiao Yang, Adam B. Glick, Nature Cell Biology InflammationCytokineImmunologyImmune RegulationChronic Inflammation	1999	909
Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis S. Paul Oh, Tsugio Seki, Kendrick A. Goss, Proceedings of the National Academy of Sciences	2000	856
Defective Angiogenesis in Mice Lacking Endoglin Dean Y. Li, Lise K. Sorensen, Benjamin S. Brooke, Science Endothelial Cell PathobiologyDevelopmental BiologyAngiogenesisDefective AngiogenesisEndothelial Cells	1999	854
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. Sela Cheifetz, Teresa Bellón, Carmela Calés, Journal of Biological Chemistry ImmunologyCellular PhysiologyAngiogenesisReceptor Tyrosine KinaseEndocytic Pathway	1992	833
Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling Marie‐José Goumans, Guðrún Valdimarsdóttir, Susumu Itoh, Molecular Cell Lateral Tgfβ/alk5Activin Receptor-like KinaseSignal TransductionDevelopmental BiologyMolecular Physiology	2003	684
Endoglin promotes endothelial cell proliferation and TGF‐β/ALK1 signal transduction Franck Lebrin, Marie‐José Goumans, Leon Jonker, The EMBO Journal	2004	644
Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells. Ellen Van Obberghen‐Schilling, N S Roche, Kathleen C. Flanders, Journal of Biological Chemistry Transcriptional RegulationDevelopmental BiologySignal TransductionTransformed CellsCell Regulation	1988	602

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