Concepedia

Reduced endothelial secretion and plasma levels of transforming growth factor-β1 in patients with hereditary hemorrhagic telangiectasia type 1

Michelle Letarte, Merry‐Lynn McDonald, Chun Li, Kirishanthy Kathirkamathamby, Santiago Vera, Satish Kumar

Cardiovascular Research · 2005 · 43 citations · 29 references

DOIFull text

Open access

Abstract

Decreased plasma TGF-beta1 levels in HHT1 patients correlate with reduced production by endothelial cells. The lower endoglin expression in these cells may alter the regulation of TGF-beta1 via Smad-independent pathways.

References

29

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Claire L. Shovlin, Alan E. Guttmacher, Elisabetta Buscarini et al. · American Journal of Medical Genetics · 2000 · 1.7K citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

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Akihiro Nakao · The EMBO Journal · 1997 · 1.1K citations · Full text

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Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

Gillian S. Ashcroft, Xiao Yang, Adam B. Glick et al. · Nature Cell Biology · 1999 · 909 citations

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Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

S. Paul Oh, Tsugio Seki, Kendrick A. Goss et al. · Proceedings of the National Academy of Sciences · 2000 · 856 citations