NADPH oxidase-dependent oxidative stress and mitochondrial damage in hippocampus of D-galactose-induced aging rats

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Andreas Bender, Kim J. Krishnan, Christopher M. Morris et al. · Nature Genetics · 2006 · 1.6K citations

Mitochondrial Function, Mitochondrial Dynamic, Genetics +8

Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes

Chenyu Zhang, György Baffy, Pascale Perret et al. · Cell · 2001 · 912 citations · Full text

Obesity, Metabolic Syndrome, Insulin Resistance +14

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

Yevgenya Kraytsberg, Elena Kudryavtseva, Ann C. McKee et al. · Nature Genetics · 2006 · 892 citations

Mitochondrial Function, Genetics, Degenerative Pathology +6

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

Marisol Corral‐Debrinski, Terzah M. Horton, Marie T. Lott et al. · Nature Genetics · 1992 · 883 citations

Neurodegenerative Diseases, Advanced Age, Brain Function +7

Does oxidative damage to DNA increase with age?

Michelle L. Hamilton, Holly Van Remmen, Jessica A. Drake et al. · Proceedings of the National Academy of Sciences · 2001 · 759 citations · Full text

Dna Damage, Genetics, Lipid Peroxidation +16