A physiological pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

Alan Poland, Edward Glover, Andrew S. Kende · Journal of Biological Chemistry · 1976 · 1.4K citations · Full text

High Affinity Binding, Chemical Biology, Toxicological Mechanism +18

Mutation and Cancer: A Model for Human Carcinogenesis2

Suresh H. Moolgavkar, Alfred G. Knudson · JNCI Journal of the National Cancer Institute · 1981 · 1.1K citations

Pathology, Cell Proliferation, Target Stem Cells +16

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

R.J. Kociba, D. G. Keyes, J Beyer et al. · Toxicology and Applied Pharmacology · 1978 · 1K citations

Medicine, Pathology, Toxicology +9

A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans

J.C. Ramsey, Melvin E. Andersen · Toxicology and Applied Pharmacology · 1984 · 675 citations

Inhalation Pharmacokinetics, Respiratory Toxicology, Medicine +8

Two-event models for carcinogenesis: incidence curves for childhood and adult tumors

Suresh H. Moolgavkar, David Venzon · Mathematical Biosciences · 1979 · 526 citations

Adult Tumors, Epidemiology, Two-event Models +9