Initial and recurrent bleeding are the major causes of death following subarachnoid hemorrhage.

Joseph Broderick, Thomas G. Brott, John E. Duldner, +2

Stroke

Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase

Jason P. Eiserich, Stephan Baldus, Marie-Luise Brennan, +8

Science

Vascular SignalingNitric OxideLipid PeroxidationImmunologyBlood Cell +16

Effects of inflammatory cytokines on the release and cleavage of the endothelial cell–derived ultralarge von Willebrand factor multimers under flow

Aubrey Bernardo, Chalmette Ball, Leticia Nolasco, +2

Blood

Reduced susceptibility to ischemic brain injury and <i>N</i> -methyl- <scp>d</scp> -aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice

Costantino Iadecola, Kiyoshi Niwa, Shigeru Nogawa, +5

Proceedings of the National Academy of Sciences

Cell DeathOxidative StressNeuroinflammationInflammationCyclooxygenase-2-deficient Mice +20

Platelet activation leads to activation and propagation of the complement system

Ian Del Conde, Miguel A. Crúz, Hui Zhang, +2

The Journal of Experimental Medicine

ImmunologyBlood CellImmunologic MechanismInflammationHematology +17

Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration

Stephan Baldus, Jason P. Eiserich, Laura Castro, +10

Journal of Clinical Investigation

Bioorganic ChemistryEcm ProteinsRedox BiologyOxidative StressInflammation +16

Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo

Frank M. Szaba, Stephen T. Smiley

Blood

Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration

Stephan Baldus, Jason P. Eiserich, Laura Castro, +10

Journal of Clinical Investigation

Ecm ProteinsRedox BiologyOxidative StressInflammationNitrotyrosine Formation +18

Amelioration of Experimental Autoimmune Encephalomyelitis in Lewis Rats by FTY720 Treatment

Masayuki Fujino, Naoko Funeshima, Yusuke Kitazawa, +4

Journal of Pharmacology and Experimental Therapeutics

Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G_12/13-Rho and G_i Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform

Naotoshi Sugimoto, Noriko Takuwa, Hiroyuki Okamoto, +2

Molecular and Cellular Biology