Concepedia

Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo

John B. Shepard, Jae‐Wook Jeong, Nita J. Maihle, S. P. O'Brien, Caroline N. Dealy

Arthritis Research & Therapy · 2013 · 54 citations · 58 references

DOIFull text

Open access

Abstract

These results demonstrate unexpected anabolic effects of EGFR signal activation in articular cartilage, and suggest the hypothesis that these effects may promote the expansion and/or activity of an endogenous EGFR-responsive cell population within the articular cartilage.

References

58

Treatment of Deep Cartilage Defects in the Knee with Autologous Chondrocyte Transplantation

Mats Brittberg, Anders Lindahl, Anders Nilsson et al. · New England Journal of Medicine · 1994 · 5.5K citations · Full text

Expression of Cre recombinase in the developing mouse limb bud driven by a <i>Prxl</i> enhancer

Malcolm Logan, James F. Martin, András Nagy et al. · genesis · 2002 · 1K citations

The surface of articular cartilage contains a progenitor cell population

Gary P. Dowthwaite, Joanna Bishop, Samantha Redman et al. · Journal of Cell Science · 2004 · 892 citations

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Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

Mei Zhu, Dezhi Tang, Qiuqian Wu et al. · Journal of Bone and Mineral Research · 2008 · 474 citations · Full text

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Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro

Marcel Jakob, O. D�marteau, Dieter Sch�fer et al. · Journal of Cellular Biochemistry · 2001 · 443 citations

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