Concepedia

Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model

Jun‐Qi Yang, Xiangshu Wen, Hongzhu Liu, Gbolahan O Folayan, Xin Dong, Min Zhou, Luc Van Kaer, Ram Raj Singh

Arthritis & Rheumatism · 2007 · 55 citations · 52 references

DOIFull text

Open access

Abstract

Germline deletion of CD1d exacerbates lupus in BWF1 mice. This finding, together with reduced thymic iNKT cells in young BWF1 mice as compared with nonautoimmune strains, implies a regulatory role of CD1d and iNKT cells during the development of lupus.

References

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An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

Olivier Lantz, Albert Bendelac · The Journal of Experimental Medicine · 1994 · 1K citations · Full text

, , +13

CD1 Recognition by Mouse NK1 <sup>+</sup> T Lymphocytes

Albert Bendelac, Olivier Lantz, Mary E. Quimby et al. · Science · 1995 · 898 citations

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Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers

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CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

Tomohiro Yoshimoto, W E Paul · The Journal of Experimental Medicine · 1994 · 842 citations · Full text

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