DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

Atsushi Hirao, Young‐Yun Kong, Shuhei Matsuoka, +6

Science

Heterozygous Germ Line <i>hCHK2</i> Mutations in Li-Fraumeni Syndrome

Daphne W. Bell, Jennifer M. Varley, Tara E. Szydlo, +11

Science

A "quickscore" method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas.

Simone Detre, G Saclani Jotti, Mitch Dowsett

Journal of Clinical Pathology

Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

Nabil Chehab, Asra Malikzay, Michael Appel, +1

Genes & Development

ApoptosisMolecular BiologyCell DeathCell CycleDominant-negative P53 Mutant +18

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

Jong‐Soo Lee, Kimberly M. Collins, Alexandra L. Brown, +2

Nature

ChromatinGenome InstabilityDna DamageMolecular BiologyCell Death +3

TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution.

Marc S. Greenblatt, Pierre O. Chappuis, Jeffrey P. Bond, +2

PubMed

Breast OncologyEngineeringPathologyMolecular BiologyStructural Distribution +14

p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition.

Pia Vahteristo, Anitta Tamminen, Petteri Karvinen, +6

PubMed

Cancer PathologyGeneticsGenetic EpidemiologyPathologyMolecular Genetics +14

p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

Tim Crook, Louise Brooks, Susan Crossland, +10

Oncogene

Brca2-associated Breast TumoursOncologySomatic VariantBreast OncologyTumor Heterogeneity +10

Characterization of Tumor-associated Chk2 Mutations

Xianglin Wu, Shelley R. Webster, Junjie Chen

Journal of Biological Chemistry

The hCds1 (Chk2)-FHA Domain Is Essential for a Chain of Phosphorylation Events on hCds1 That Is Induced by Ionizing Radiation

Chang Hun Lee, Jay H. Chung

Journal of Biological Chemistry