Respiratory distress and perinatal lethality in Nedd4-2-deficient mice

Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice

Marcus Mall, Barbara R. Grubb, Jack R. Harkema et al. · Nature Medicine · 2004 · 892 citations

Inflammation, Fibrosis, Allergy +9

Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice

Edith Hümmler, Pierre Barker, John T. Gatzy et al. · Nature Genetics · 1996 · 876 citations · Full text

Acute Lung Injury, Allergy, Lung Inflammation +10

Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na+ channel cell surface expression

Christophe Debonneville · The EMBO Journal · 2001 · 701 citations · Full text

Signal Transduction, Molecular Physiology, Signaling Pathway +8

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

Sharad Kumar, Yasuhiro Tomooka, Makoto Noda · Biochemical and Biophysical Research Communications · 1992 · 549 citations

Knockout Mouse, Developmental Biology, Brain Development +12

Serum and Glucocorticoid-regulated Kinase Modulates Nedd4-2-mediated Inhibition of the Epithelial Na+Channel

Peter M. Snyder, Diane R. Olson, Brittany C. Thomas · Journal of Biological Chemistry · 2002 · 452 citations · Full text