Phosphorylation of Nedd4‐2 by Sgk1 regulates epithelial Na+ channel cell surface expression

Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits

Cecilia M. Canessa, Laurent Schild, Gary Buell et al. · Nature · 1994 · 2K citations

Natural Sciences, Biochemistry, Biophysics +13

Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel

Richard A. Shimkets, David G. Warnock, Christopher M. Bositis et al. · Cell · 1994 · 1.3K citations

Life Sciences, Genetics, Molecular Genetics +15

Epithelial sodium channel related to proteins involved in neurodegeneration

Cecilia M. Canessa, Jean‐Daniel Horisberger, Bernard C. Rossier · Nature · 1993 · 922 citations

Life Sciences, Cell Biology, Neuroscience +12

Sgk1-Dependent Stimulation of Cardiac Na⁺/H⁺Exchanger Nhe1 by Dexamethasone

Jakob Voelkl, Venkanna Pasham, Mohamed Siyabeldin E. Ahmed et al. · Cellular Physiology and Biochemistry · 2013 · 859 citations · Full text

Life Sciences, Pharmacology, Physiology +14

WW domains of Nedd4 bind to the proline‐rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

Olivier Staub, Sascha E. Dho, P Henry et al. · The EMBO Journal · 1996 · 850 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +7