Concepedia

TGF-β Promotes the Establishment of Renal Cell Carcinoma Bone Metastasis

Scott L. Kominsky, Michèle Doucet, Kelly Brady, Kristy Weber

Journal of Bone and Mineral Research · 2006 · 86 citations · 28 references

DOIFull text

Open access

Abstract

TGF-beta1 stimulation of RBM cells plays a role in promoting tumor growth and subsequent osteolysis in vivo, likely through the initiation of tumor-promoting paracrine interactions between tumor cells and the bone microenvironment. These data suggest that inhibition of TGF-beta1 signaling may be useful in the treatment of RBM.

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