The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells

Global cancer statistics

Ahmedin Jemal, Freddie Bray · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

Colorectal cancer statistics, 2014

Rebecca L. Siegel, Carol DeSantis, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2014 · 2.6K citations · Full text

Epidemiology, Cancer Epidemiology, Medicine +12

BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and Indirectly

Tomomi Kuwana, Lisa Bouchier‐Hayes, Jerry E. Chipuk et al. · Molecular Cell · 2005 · 1.2K citations · Full text

Molecular Physiology, Signal Transduction, Mitochondrial Function +9

Structure of Bax

Motoshi Suzuki, Richard J. Youle, Nico Tjandra · Cell · 2000 · 1.1K citations · Full text

Crystal Structure, Engineering, Physics +4

Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

Charles M. Rudin, Christine L. Hann, Edward B. Garon et al. · Clinical Cancer Research · 2012 · 542 citations · Full text