Antimicrobial Agents and Chemotherapy · 2004 · 106 citations · 8 references
Life SciencesInfectious DiseasesMolecular GeneticsMolecular VirologyPharmacogeneticsVirologyAntiretroviral TherapyAntiviral Drug ResistanceAntiviral ResistanceHiv TestingMutation AnalysisViral MutationAntiviral Resistance MutationsDrug Resistance MutationsGenotypic Resistance TestingNon-nucleoside Reverse Transcriptase InhibitorsNucleoside Reverse Transcriptase InhibitorsProtease Inhibitor ResistanceResistance-associated MutationsReverse Transcriptase Inhibitor Resistance
In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinical significance of these common patterns may lead to improved treatment recommendations for a large proportion of patients for whom antiretroviral therapy is failing.
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