Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.3K citations · Full text

Replicative Senescence, Developmental Biology, Aging +14

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5K citations · Full text

Developmental Biology, Oncogenic Agent, Cellular Senescence +6

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Athena W. Lin, Marta Barradas, James C. Stone et al. · Genes & Development · 1998 · 921 citations · Full text

Mek/mapk Mitogenic Signaling, Developmental Biology, Aging +15

Senescence of human fibroblasts induced by oncogenic Raf

Jiyue Zhu, Douglas Woods, Martin McMahon et al. · Genes & Development · 1998 · 800 citations · Full text

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

Douglas Woods, David Parry, Holly Cherwinski et al. · Molecular and Cellular Biology · 1997 · 646 citations · Full text

Cell Proliferation, Cell Cycle, Raf Activity +17