Concepedia

Identification of the C(6)-S-conjugate of leukotriene a with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity

Robert A. Lewis, Jeffrey M. Drazen, K. Frank Austen, David A. Clark, E.J. Corey

Biochemical and Biophysical Research Communications · 1980 · 265 citations · 17 references

Concepts

MedicineChemistryPharmacologyBiochemical PharmacologyHypersensitivityStructure-activity RelationshipsAnaphylaxisConjugation ReactionsStructure-activity Relationship AnalysisBiological Activity FeaturesCysteine-related Sulfur CompoundsLeukotriene Pharmacology

References

17

The release of histamine and formation of a slow‐reacting substance (SRS‐A) during anaphylactic shock

W. E. Brocklehurst · The Journal of Physiology · 1960 · 638 citations

Life Sciences, Immunology, Pharmacology +10

THE LIBERATION OF A SLOW‐REACTING SMOOTH MUSCLE‐STIMULATING SUBSTANCE IN ANAPHYLAXIS

C. H. Kellaway, E. R. Trethewie · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · 1940 · 417 citations

Life Sciences, Pharmacology, Physiology +10

Stereospecific total synthesis of a "slow reacting substance" of anaphylaxis, leukotriene C-1

E. J. Corey, David A. Clark, Giichi Goto et al. · Journal of the American Chemical Society · 1980 · 374 citations

Natural Sciences, Chemistry, Pharmacology +8

IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG

Robert P. Orange, William G. Austen, K. Frank Austen · The Journal of Experimental Medicine · 1971 · 343 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Leukotriene a: Stereochemistry and enzymatic conversion to leukotriene B

Olof Rådmark, Curt Malmsten, Bengt Samuelsson et al. · Biochemical and Biophysical Research Communications · 1980 · 162 citations

Life Sciences, Chemistry, Pharmacology +11