Synthese hochwirksamer Oktapeptide mit der vermutlichen Aminosäuresequenz des noch unbekannten Hypertensins II aus Rinderserum (Val⁵‐Hypertensin II und Val⁵‐Hypertensin II‐Asp‐β‐amid)

Abstract

Abstract The synthesis of two octapeptides, H · Asp(β‐NH 2 )‐Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · OH and H · Asp(β‐OH)‐Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · OH, is described in detail (preliminary communications see footnote 3). The products show a very strong hypertensive activity, and may be identical with the hitherto unknown Val 5 ‐hypertensin II of ox blood.