Synthesis and hybridization properties of amide-linked thymidine dimers incorporated into oligodeoxynucleotides

Gene Synthesis Machines: DNA Chemistry and Its Uses

Marvin H. Caruthers · Science · 1985 · 791 citations

Life Sciences, Biotechnology, Molecular Biology +15

Peptide nucleic acids (PNA). Oligonucleotide analogs with an achiral peptide backbone

Ole Buchardt, Peter E. Nielsen, Rolf H. Berg · Journal of the American Chemical Society · 1992 · 736 citations

Life Sciences, Biochemistry, Molecular Biology +12

Antisense and Antigene Properties of Peptide Nucleic Acids

Jeffery C. Hanvey, Nancy J. Peffer, John Bisi et al. · Science · 1992 · 536 citations

Life Sciences, Genetics, Molecular Biology +17

Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages

Carol J. Marcus-Sekura, Amy M. Woerner, Kazuo Shinozuka et al. · Nucleic Acids Research · 1987 · 175 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +12

Total chemical synthesis of a 77-nucleotide-long RNA sequence having methionine-acceptance activity.

Kelvin K. Ogilvie, Nassim Usman, K. Nicoghosian et al. · Proceedings of the National Academy of Sciences · 1988 · 150 citations · Full text

Pharmacy, Biotechnology, Molecular Biology +17