Studies in Applied Mathematics · 1972 · 599 citations · 11 references
MedicineCancer BiologyOncologyCarcinogenesisHistologyTumor ProgressionCell Growth KineticsDiffusion ProcessesMalignant TumorsReaction-diffusion SystemsTumor Growth KineticsTumor HistopathologyDormant StagesGrowth Inhibition KineticsReaction-diffusion In TissuesTissue Growth ModelingTumor Growth DynamicsTumor Growth Inhibition ModelingTumor Growth ModelingTumor Growth Rate
A simple mathematical model of tumor growth by diffusion is constructed in order to examine and evaluate different hypotheses concerning the evolution of a solid carcinoma. A primary objective is to infer the chemical source of growth inhibition from the most easily obtained data, namely, the outer radius of the nodule as a function of time and a histological examination of the final dormant state. In section 6 some of the conclusions of this study relating to a prototype experiment and described with as little mathematics as possible.
11
C. J. Tranter · Journal of the Mechanics and Physics of Solids · 1959 · 18.5K citations
J. W. Westwater, H. G. Drickamer · Journal of the American Chemical Society · 1957 · 4.1K citations
ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS
Judah Folkman, Ezio Merler, Charles M. Abernathy et al. · The Journal of Experimental Medicine · 1971 · 1.7K citations · Full text
Medicine, Cancer Biology, Oncology +15
Judah Folkman · Annals of Surgery · 1972 · 1.2K citations · Full text
Medicine, Pediatrics, Surgery +2