RDC‐Enhanced NMR Spectroscopy in Structure Elucidation of Sucro‐Neolambertellin

Abstract

A new method based on NMR spectroscopy is introduced to determine the absolute configuration of natural compounds and has been successfully applied to sucro-neolambertellin. The method relies on the measurement of residual dipolar couplings (RDCs), which allow the absolute configuration of unknown stereocenters to be related with known stereocenters (see picture). The approach is used to determine the configuration of the D-threo-2,5-hexodiulofuranose moiety by relating it to α-D-glucose.