Effects of clarithromycin on lansoprazole pharmacokinetics between<i>CYP2C19</i>genotypes

Abstract

The present study indicates that there are significant drug interactions between lansoprazole and clarithromycin in all CYP2C19 genotype groups probably through CYP3A inhibition. The bioavailability of lansoprazole might, to some extent, be increased through inhibition of P-glycoprotein during clarithromycin treatment.