Enteral Glutamine and/or Arginine Supplementation Have Favorable Effects on Oxidative Stress Parameters in Neonatal Rat Intestine

Mustafa Kul, Sabahattin Vurucu, Erkan Demirkaya, Turan Tunç, Seçil Aydınöz, Cihan Meral, Vural Kesik, Faruk Alpay

Journal of Pediatric Gastroenterology and Nutrition · 2009 · 46 citations · 27 references

Abstract

Enteral glutamine alone or in the presence of arginine has favorable effects on oxidative stress not only in experimental models of hypoxia-reoxygenation, but also in healthy newborn rats. This suggests that in premature neonates with insufficient oxidative resistance, glutamine and arginine supplementation may help prevent necrotizing enterocolitis.

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