Concepedia

Constitutional CHEK2mutations are infrequent in early-onset and familial breast/ovarian cancer patients from Pakistan

Muhammad Usman Rashid, Noor Muhammad, Saima Faisal, Asim Amin, Ute Hamann

BMC Cancer · 2013 · 25 citations · 44 references

DOIFull text

Open access

Abstract

Our findings suggest that CHEK2 mutations may not contribute significantly to breast/ovarian cancer risk in Pakistani women.

References

44

Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations

Deborah J. Thompson, Richard S. Houlston, Catherine Phelan · Nature Genetics · 2002 · 1.1K citations · Full text

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The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Jacob Falck, Niels Mailand, Randi G. Syljuåsen et al. · Nature · 2001 · 1.1K citations

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Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing

Tom Walsh, Silvia Casadei, Ming K. Lee et al. · Proceedings of the National Academy of Sciences · 2011 · 929 citations · Full text

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Ataxia telangiectasia-mutated phosphorylates Chk2 <i>in vivo</i> and <i>in vitro</i>

Shuhei Matsuoka, Galit Rotman, Akira Ogawa et al. · Proceedings of the National Academy of Sciences · 2000 · 818 citations · Full text

Chk2/hCds1 functions as a DNA damage checkpoint in G<sub>1</sub>by stabilizing p53

Nabil Chehab, Asra Malikzay, Michael Appel et al. · Genes & Development · 2000 · 784 citations · Full text

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