Concepedia

Do Idebenone and Vitamin Therapy Shorten the Time to Achieve Visual Recovery in Leber Hereditary Optic Neuropathy?

Yukihiko Mashima, K Kigasawa, Masato Wakakura, Yoshihisa Oguchi

Journal of Neuro-Ophthalmology · 2000 · 137 citations · 12 references

DOI

Abstract

Results suggest that the administration of idebenone, vitamin B2, and vitamin C sped the recovery of vision in patients with LHON.

References

12

The clinical features of Leber's hereditary optic neuropathy defined by the presence of a pathogenic mitochondrial DNA mutation

Paul Riordan‐Eva, M D Sanders, G.G. Govan et al. · Brain · 1995 · 482 citations

The Clinical Characteristics of Pedigrees of Leber's Hereditary Optic Neuropathy With the 11778 Mutation

Nancy J. Newman, Marie T. Lott, Douglas C. Wallace · American Journal of Ophthalmology · 1991 · 399 citations

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Leber's Hereditary Optic Neuropathy

Donald R. Johns · Archives of Ophthalmology · 1992 · 244 citations

Inhibition of lipid peroxidation by a novel compound, idebenone (CV-2619).

Masahiro Suno, Akinobu Nagaoka · The Japanese Journal of Pharmacology · 1984 · 78 citations · Full text

, , +4

Stimulation of the respiratory and phosphorylating activities in rat brain mitochondria by idebenone (CV‐2619), a new agent improving cerebral metabolism

Yasuo Sugiyama, Takeshi Fujita · FEBS Letters · 1985 · 68 citations · Full text

, , +24