Concepedia

Poly(ADP-Ribose) Polymerase Inhibition Reduces Atherosclerotic Plaque Size and Promotes Factors of Plaque Stability in Apolipoprotein E–Deficient Mice

Karine Oumouna‐Benachour, Chetan P. Hans, Yasuhiro Suzuki, Amarjit S. Naura, Rahul Datta, Souad Belmadani, Kenneth B. Fallon, Cooper Woods, A. Hamid Boulares

Circulation · 2007 · 109 citations · 18 references

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Abstract

Our results suggest that PARP inhibition interferes with plaque development and may promote plaque stability, possibly through a reduction in inflammatory factors and cellular changes related to plaque dynamics. PARP inhibition may prove beneficial for the treatment of atherosclerosis.

References

18

Role of Poly(ADP-ribose) Polymerase (PARP) Cleavage in Apoptosis

A. Hamid Boulares, Alexander G. Yakovlev, Vessela S. Ivanova et al. · Journal of Biological Chemistry · 1999 · 887 citations · Full text

, , +11

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

Csaba Szabó, Basilia Zingarelli, Michael O′Connor et al. · Proceedings of the National Academy of Sciences · 1996 · 623 citations · Full text

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Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

Ingrid U. Schraufstätter, Daniel B. Hinshaw, Paul A. Hyslop et al. · Journal of Clinical Investigation · 1986 · 513 citations · Full text

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Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

Ingrid U. Schraufstätter, Paul A. Hyslop, Daniel B. Hinshaw et al. · Proceedings of the National Academy of Sciences · 1986 · 462 citations · Full text

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Elevated Levels of Oxidative DNA Damage and DNA Repair Enzymes in Human Atherosclerotic Plaques

Wim Martinet, Michiel Knaapen, Guido R.Y. De Meyer et al. · Circulation · 2002 · 442 citations