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Studies on the Inhibitory Effects of Caffeoylquinic Acids on Monocyte Migration and Superoxide Ion Production
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1995
Year
Lipid PeroxidationRedox BiologyTricaffeoyl DerivativePolyphenolicsSuperoxide Ion ProductionOxidative StressInflammationMedicinal ChemistryMonocyte MigrationSuperoxide Anion ProductionPhytopharmacologyPhytochemicalBiochemistryCaffeoylquinic AcidsReactive Oxygen SpeciePharmacologyAnti-inflammatoryNatural SciencesPhytochemistryMedicineCarbonyl Metabolism
Three caffeoylquinic acids, isolated from the Peruvian plants Tessaria integrifolia and Mikania cordifolia that are used medicinally as anti-inflammatory agents, were tested for their activities on monocyte migration and superoxide anion production. 3,5-Di-O-caffeoylquinic and 4,5-di-O-caffeoylquinic acids exhibited an appreciable anti-inflammatory activity in vitro, while the tricaffeoyl derivative was inactive.