Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

Sandeep Burma, Benjamin P. Chen, Michael Murphy et al. · Journal of Biological Chemistry · 2001 · 1.9K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Superoxide dismutase as a target for the selective killing of cancer cells

Peng Huang, Feng Li, Eli Oldham et al. · Nature · 2000 · 841 citations

Life Sciences, Cancer Biology, Oncology +16

Malignant Cells Can Be Sensitized to Undergo Growth Inhibition and Apoptosis by Arsenic Trioxide Through Modulation of the Glutathione Redox System

Jie Dai, Rona Singer Weinberg, Samuel Waxman et al. · Blood · 1999 · 531 citations

Life Sciences, Cancer Biology, Oncology +17

DNA double-strand breaks measured in individual cells subjected to gel electrophoresis.

Peggy L. Olive, D. Włodek, Judit P. Banáth · PubMed · 1991 · 331 citations

Medicine, Cell Biology, Molecular Biology +17

Oxidative Stress-mediated Apoptosis

Jing Wen, Kyung-Ran You, So-Youn Lee et al. · Journal of Biological Chemistry · 2002 · 323 citations · Full text

Medicine, Oncology, Pharmacology +14