Development of a three‐dimensional culture model of prostatic epithelial cells and its use for the study of epithelial‐mesenchymal transition and inhibition of PI3K pathway in prostate cancer

Abstract

Taken together, we established a 3D culture model of human prostatic epithelial cells with structural and functional relevance to normal prostate gland and prostate cancer development and also demonstrated that this 3D model might be useful to assess the ability of drugs to restore differentiation as a potential surrogate measure of efficacy for prostate cancer therapy.