Concepedia

Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species

Parag Goyal, Friedrich Grimminger, Cornelia Hegel, Lucius Bader, Frank Rose, Ludger Fink, Hossein Ardeschir Ghofrani, Ralph T. Schermuly, Harald Schmidt, Werner Seeger,

Free Radical Biology and Medicine · 2004 · 187 citations · 46 references

DOI

Concepts

References

46

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

, , +17

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

, , +17

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

, , +14

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

, , +16

Purification and Characterization of Hypoxia-inducible Factor 1

Guang L. Wang, Gregg L. Semenza · Journal of Biological Chemistry · 1995 · 2.1K citations · Full text

, , +14