Concepedia

Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis*

Josef G. Heuer, Ganesh R. Sharma, Bruce Gerlitz, Tonghai Zhang, Dianna L. Bailey, Chunjin Ding, David T. Berg, Douglas J. Perkins, Eddie J. Stephens, Kimberly C. Holmes,

Critical Care Medicine · 2004 · 69 citations · 38 references

DOI

Abstract

The data from this study indicate that an early decrease in protein C concentration predicts poor outcome in a rat sepsis model. The data further indicate that increases in the CXC chemokines macrophage inflammatory protein-2 and KC precede poor outcome.

References

38

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

Derek C. Angus, Walter T. Linde‐Zwirble, Jeffrey Lidicker et al. · Critical Care Medicine · 2001 · 8.5K citations

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Gordon R. Bernard, Jean‐Louis Vincent, Pierre‐François Laterre et al. · New England Journal of Medicine · 2001 · 6.1K citations · Full text

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

Charles J. Fisher · JAMA · 1994 · 932 citations

Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome

Edward Abraham · JAMA · 1995 · 825 citations

Multiple-Organ-Failure Syndrome

Archives of Surgery · 1986 · 805 citations