High Efficacy of Combination Therapy Using PI3K/AKT Inhibitors with Androgen Deprivation in Prostate Cancer Preclinical Models

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

Kathryn O’Reilly, F. Rojo, Qing‐Bai She et al. · Cancer Research · 2006 · 2.6K citations · Full text

Medicine, Oncology, Pharmacology +16

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Arkaitz Carracedo, Li Ma, Julie Teruya‐Feldstein et al. · Journal of Clinical Investigation · 2008 · 1.4K citations · Full text

Medicine, Oncology, Pharmacology +17

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

Brett S. Carver, Caren Chapinski, John Wongvipat et al. · Cancer Cell · 2011 · 1.2K citations · Full text

Life Sciences, Molecular Biology, Oncology +16

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

Sarat Chandarlapaty, Ayana Sawai, Maurizio Scaltriti et al. · Cancer Cell · 2011 · 958 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +14

PTEN-deficient cancers depend on PIK3CB

Susan Wee, Dmitri Wiederschain, Sauveur-Michel Maira et al. · Proceedings of the National Academy of Sciences · 2008 · 552 citations · Full text

Life Sciences, Cell Biology, Oncology +17