Human Retroviral gag- and gag-pol-like Proteins Interact with the Transforming Growth Factor-β Receptor Activin Receptor-like Kinase 1

Abstract

Mutations in activin receptor-like kinase 1 (ALK1), a transforming growth factor (TGF)-β type I receptor, lead to the vascular disorder hereditary hemorrhagic telangiectasia caused by abnormal vascular remodeling. The underlying molecular cause of this disease is not well understood. Identifying binding partners for ALK1 will help to understand its cellular function. Using the by a by a a of in in is the a a of type I binding to ALK1 is by a ALK1 well of ALK1 in of is the of a of the Mutations in activin receptor-like kinase 1 (ALK1), a transforming growth factor (TGF)-β type I receptor, lead to the vascular disorder hereditary hemorrhagic telangiectasia caused by abnormal vascular remodeling. The underlying molecular cause of this disease is not well understood. Identifying binding partners for ALK1 will help to understand its cellular function. Using the by a by a a of in in is the a a of type I binding to ALK1 is by a ALK1 well of ALK1 in of is the of a of the receptor-like kinase 1 activin receptor-like kinase transforming growth hereditary hemorrhagic of activin receptor-like kinase transforming growth hereditary hemorrhagic of to the of type I for of the of growth of of for the is is a of type I type kinase of to type of type I type I in the of the kinase of the type type I of the a to the by the kinase the in ALK1 in a type receptor, lead to the vascular disorder disorder by The of ALK1 in binding for ALK1 a type I for activin cellular in ALK1 ALK1 the ALK1 is a to ALK1 is a for by a the well the in a in by a ALK1 ALK1 the in ALK1 not the is ALK1 in to by ALK1 the to ALK1 binding a the of a is of by the a the for caused by of ALK1 in not type I in in in in in in of of the in a the in the the a the the the of the of the is to the for the in the the the the in a the the growth in the by for type in this ALK1 of the in the a in the ALK1 the The to the the the the the the The for the of the type I the by in to the of the ALK1 the of the of the of ALK1 for the the of ALK1 in the of the of ALK1 the of of The The to the the of the The The by the of in to the of the to the of the to the of the in to the of the in the The of of the by a to the the to the by the the the of in a a of by the the the 1 in 1 of to of of 1 of in a of for for for for 1 for a The a of by The the by The of in the of not to in binding of to of for 1 in the in to of of to the the of 1 in 1 of the in of 1 a for The of in for of of the The in of in of of by for the the to the the the cellular of 1 the for in the for in for in the the well the in a in the in a in the for 1 in in a the the 1 the for the for 1 in a The for a the the in type I type The the to the the of in a of a of the a a of the by the the the The to the for the a the for in of to the the the The of to the of for partners for the ALK1 to in the 1 for the of the in a to of of to the of a for a function. its the of the for of of a a of by the of to the the of by a for the ALK1 in the the of a to to a to for a of the molecular is ALK1 to for by for ALK1 for the ALK1 binding in the of for a a its in well in in of the a the is of to the for the this a the of the to the the a the the its the is a of of the a a of a the in of the of the its for a to of The to the of the the to the is the is to the a is of the of the a for The is in is by the by The is to in to to in of binding for of to the the ALK1 to the ALK1 to the to the The of the in the in of the is in a to to the of of in for of is in The for this is the the 1 of a to of in the for the of The molecular for is the the is to to a of to is a of the of is The of a the is is for to the of a The of the for for for by a the to by for by the the by of the by 1 a for The is to the of of the ALK1 in to by by not is by The the to is to in ALK1 the not to the the binding is in the in the the in in to in this is the of the of Using the is in by not to the in for the by not not for the The of in is in of in by for the of 1 the of the in a of in for the the in the of by the a of the The by well the is not the of this in in the of the the in for the the of The the of in of for the this not ALK1 to the growth a ALK1 binding for the growth for for the in the to The for for of the in ALK1 binding of growth growth not growth The of is a in ALK1 the a to the ALK1 in ALK1 to the not in the the is to ALK1 binding in The the to a for its to binding to ALK1 in ALK1 the the of The the of in binding the in a to the not binding not to the binding this the is in in the not to not this binding is in of of the to type I of the the for the not of the the for by for the to by by to the of the to the growth ALK1 a for binding to in in a the not I factor ALK1 ALK1 is a receptor, The to well to is a for ALK1 well a of in ALK1 the the ALK1 ALK1 ALK1 ALK1 a a in ALK1 ALK1 by ALK1 The of in in the of is a of type I ALK1 The of ALK1 in the type I the the ALK1 in the of The in in the of The in of the in the the The is for ALK1 in of a receptor, a of in the this for the in cellular the of is to the the for in to to of ALK1 for the is in the for the is in of by the in the in in the a of not the of ALK1 its cellular of ALK1 not the of type I cellular the type I in in the not of type I ALK1 in type I of the of the for of ALK1 the to by by for of a The of to the well to the in of to the a of the a in the the the of to ALK1 to a of of by of in the type I ALK1 of for of ALK1 not the of the a ALK1 in not in ALK1 of the cellular of the not in a in the to the the of the the not to in in cellular for ALK1 in the in of not the type I of the in not to ALK1 binding well cellular this ALK1 in for ALK1 a molecular of a molecular The molecular the ALK1 the by of ALK1 the to ALK1 by a not of the ALK1 not the not the cellular in the the ALK1 the of the the the kinase a to the the of the the ALK1 to the ALK1 the a ALK1 is the the the ALK1 the in the a ALK1 the a in the ALK1 in in not The the ALK1 the of the the the the of the of ALK1 the the to partners for the type I The a of is a in of in Using the of in the of the of the a for the in the is a in of in is by of to the the of to a a to the is by of The is by in for is the of a for not by by is the of is the for in the of its a is in this the of the the is a in of in is to is in in is in in in a for in is not by in the of to the of in is a of a of for by The to a of in is the of the of the is in for a for to to the a in in of the to in the binding the the the for the of not to not cellular to by binding to a to in in in in in is in the of disorder to the is by a in for a in not in the ALK1 of to a is this is to the of by the in for not is for binding to the a is in the of in by the is of binding to a is to in the the ALK1 is in the to in in the not in the The the a is the type I of this is by binding to this for ALK1 of ALK1 in of type I to a of the ALK1 the ALK1 to not in of cellular the of The caused by the of ALK1 ALK1 to ALK1 to the the not for ALK1 in the The of ALK1 in to of its the the of in the the ALK1 is the is to the of ALK1 The binding of to in this by its type of is a in well in the a the a for the the is in this The by not in in The of a to the to the receptor-like kinase 1 activin receptor-like kinase transforming growth hereditary hemorrhagic of activin receptor-like kinase transforming growth hereditary hemorrhagic of to the of type I for of the of growth of The of for the is is a of type I type kinase of to type of type I type I in the of the kinase of the type type I of the a to the by the kinase the Mutations in ALK1 in a type receptor, lead to the vascular disorder disorder by The of ALK1 in binding for ALK1 a type I for activin cellular in ALK1 ALK1 the ALK1 is a to ALK1 is a for by a the well the in a in by a ALK1 ALK1 the in ALK1 not the is ALK1 in to by ALK1 the to ALK1 binding a the of a is of by the a the for 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type I type The the to the the of in a of a of the a a of the by the the the The to the for the a the for in of to the the the The of to the of for in in in in in in of of the in a the in the the a the the the of the of the is to the for the in the the the the in a the the growth in the by for type in this ALK1 of the in the a in the ALK1 the The to the the the the the the The for the of the type I the by in to the of the ALK1 the of the of the of The ALK1 for the the of ALK1 in the of the of ALK1 the of of The The to the the of the The The by the of in to the of the to the of the to the of the in to the of the in the The of of the by a to the the to the by the the the of in a a of by the the the 1 in 1 of to of of 1 of in a of for for for for 1 for a The a of by The the by The of in the of not to in binding of to of for 1 in the in to of of to the the of 1 in 1 of the in of 1 a for The of in for of of the The in of in of of by for the the to the the the cellular of 1 the for in the for in for in the the well the in a in the in a in the for 1 in in a the the 1 the for the for 1 in a The for a the the in type I type The the to the the of in a of a of the a a of the by the the the The to the for the a the for in of to the the the The of to the of for partners for the ALK1 to in the 1 for the of the in a to of of to the of a for a function. its the of the for of of a a of by the of to the the of by a for the ALK1 in the the of a to to a to for a of the molecular is ALK1 to for by for ALK1 for the ALK1 binding in the of for a a its in well in in of the a the is of to the for the this a the of the to the the a the the its the is a of of the a a of a the in of the of the its for a to of The to the of the the to the is the is to the a is of the of the a for The is in is by the by The is to in to to in a to to the of of in for of is in The for this is the the 1 of a to of in the for the of The molecular for is the the is to to a of to is a of the of is The of a the is is 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the for the of The molecular for is the the is to to a of to is a of the of is The of a the is is for to the of a The of the for for to is to in ALK1 the not to the the binding is in the in the the in in to in this is the of the of Using the is in by not to the in for the by not not for the The of in is in in the of by the a of the The by well the is not the of this in in the of the the in for the the of The the of in of for the this not ALK1 to the growth a ALK1 binding for the growth for for the in the to The for for of the in ALK1 binding of growth growth not growth The of is a in ALK1 the a to the ALK1 in ALK1 to the not in the the is to ALK1 binding in The the to a for its to binding to ALK1 in ALK1 the the of The the of in binding the in a to the not binding not to the binding this the is in in the not to not this binding is in of of the to type I of the the for the not to the of the to the growth ALK1 a for binding to in in a the not I factor ALK1 ALK1 is a receptor, The to well to is a for ALK1 well a of in ALK1 the the ALK1 ALK1 ALK1 ALK1 a a in ALK1 ALK1 by ALK1 The of in in the of is a of type I ALK1 in of a receptor, a of in the this for the in cellular the of is to the the for in to to the of ALK1 its cellular of ALK1 not the of type I cellular the type I in in the not for of a The of to the well to the in of to the a of the a in the the the of to ALK1 to a of of by of in the type I ALK1 of for of ALK1 not the of the a ALK1 in not in ALK1 of the cellular of the not in a in the to the the of the the not to in in cellular for ALK1 in the in of not the type I of the in not to ALK1 binding well cellular this ALK1 in for ALK1 a molecular of a molecular The molecular the ALK1 the by of ALK1 the to ALK1 by a not of the ALK1 not the not the cellular in the the ALK1 the of the the the kinase a to the the of the the ALK1 to the ALK1 the a ALK1 is the the the ALK1 the in the a ALK1 the a in the ALK1 in in not The the ALK1 the of the the the the of the of ALK1 the the to partners for the type I The a of is a in of in Using the of in the of the of the a for the in the is a in of in is by of to the the of to a a to the is by of The is by in for is the of a for not by by is the of is the for in the of its a is in this the of the the is a in of in is to is in in is in in in a for in is not by in the of to the of in is a of a of for by The to a of in is the of the of the is in for a for to to the a in in of the to in the binding the the the for the of not to not cellular to by binding to a to in in in in in is in the of disorder to the is by a in for a in not in the ALK1 of to a is this is to the of by the in for not is for binding to the a is in the of in by the is of binding to a is to in the the ALK1 is in the to in in the not in the The the a is the type I of this is by binding to this for ALK1 of ALK1 in of type I to a of the ALK1 the ALK1 to not in of cellular the of The caused by the of ALK1 ALK1 to ALK1 to the the not for ALK1 in the The of ALK1 in to of its the the of in the the ALK1 is the is to the of ALK1 The binding of to in this by its type of is a in well in the a the a for the the is in this The by not in in The of a to the to the the to partners for the type I The a of is a in of in Using the of in the of the of the a for the in the is a in The of in is by of to the the of to a a to the is by of The is by in for is the of a for not by by is the of is the for in the of its a is in this the of the the is a in of in is to is in in is in in in a for in is not by in the of to the of in is a of a of for by The to a of in is the of the of the is in for a for to to the a in in of the to in the binding the the the for the of not to not cellular to by binding to a to in in in in in is in the of disorder to the is by a in for a in not in the ALK1 of to a is this is to the of by the in for not is for binding to the a is in the of in by the is of binding to a is to in the the ALK1 is in the to in in the not in the The the a is the type I of this is by binding to this for ALK1 of ALK1 in of type I to a of the ALK1 the ALK1 to not in of cellular the of The caused by the of ALK1 ALK1 to ALK1 to the the not for ALK1 in the The of ALK1 in to of its the the of in the the ALK1 is the is to the of ALK1 The binding of to in this by its type of is a in well in The the a the a for the the is in this The by not in in The of a to the to the for the for