Rapamycin is a neuroprotective treatment for traumatic brain injury

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Taichi Hara, Kenji Nakamura, Makoto Matsui et al. · Nature · 2006 · 3.8K citations

Neural Cells, Cell Autophagy, Neurodegenerative Diseases +12

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Masaaki Komatsu, Satoshi Waguri, Tomoki Chiba et al. · Nature · 2006 · 3.4K citations

Cell Autophagy, Neurodegenerative Diseases, Mitophagy +12

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Xiao Huan Liang, Saadiya Jackson, Matthew Seaman et al. · Nature · 1999 · 3.3K citations

Cell Autophagy, Mitophagy, Cell Regulation +11

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Brinda Ravikumar, Zdenek Berger, J. Eric Davies et al. · Nature Genetics · 2004 · 2.3K citations · Full text

Cell Autophagy, Mitophagy, Medicine +9

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

Markus Guba, Philipp von Breitenbuch, Markus Steinbauer et al. · Nature Medicine · 2002 · 1.7K citations

Oncology, Angiogenesis, Metastatic Tumor Growth +9