Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

Luke Whitesell, Edward G. Mimnaugh, B. de Costa et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations · Full text

Molecular Regulation, Molecular Biology, Hsp Participation +17

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

C. Erec Stebbins, Alicia A. Russo, Christine Schneider et al. · Cell · 1997 · 1.4K citations · Full text

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

Uwe Senftleben, Yixue Cao, Gutian Xiao et al. · Science · 2001 · 1.3K citations

Immunology, Ikappab Degradation, Inflammation +21

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

Hailing Hsu, Jianing Huang, Hong-Bing Shu et al. · Immunity · 1996 · 1.2K citations · Full text

Signal Transduction, Cell Regulation, Molecular Pathway +12

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

Michelle A. Kelliher, Stefan Grimm, Yasumasa Ishida et al. · Immunity · 1998 · 1.1K citations · Full text

Inflammation, Signal Transduction, Signaling Pathway +10