Concepedia

The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination

Dik C. van Gent, Dale A. Ramsden, Martin Gellert

Cell · 1996 · 285 citations · 15 references

Open access

Concepts

Life SciencesGeneticsMolecular GeneticsDna RepairImmunogeneticsRecombinationImmunoglobulin Gene RearrangementRecombination InitiationRecombination ProteinsV(d)j RecombinationV(d)j Recombination DefectsV(d)j Recombination ErrorsV(d)j Recombination MachineryV(d)j Recombination MechanismV(d)j Recombination Regulation

References

15

Somatic generation of antibody diversity

Susumu Tonegawa · Nature · 1983 · 4K citations

Life Sciences, Biotechnology, Immunology +14

Somatic generation of antibody diversity.

PubMed · 1976 · 3.3K citations

Life Sciences, Biotechnology, Immunology +14

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

J. Fraser McBlane, Dik C. van Gent, Dale A. Ramsden et al. · Cell · 1995 · 709 citations · Full text

Life Sciences, Genetics, Molecular Biology +12

V(D)J recombination: a functional definition of the joining signals.

Joanne E. Hesse, Michael R. Lieber, Kiyoshi Mizuuchi et al. · Genes & Development · 1989 · 466 citations · Full text

Life Sciences, Immunology, Molecular Biology +16

V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

David B. Roth, Joseph P. Menetski, Pamela B. Nakajima et al. · Cell · 1992 · 447 citations

Life Sciences, Genetics, Molecular Biology +15