Synthesis and in vitro antiproliferative activity against human cancer cell lines of novel 5-(4-methyl-benzylidene)-thiazolidine-2,4-diones

Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents

Brian F. Meyer, N. R. Ferrigni, J. E. Putnam et al. · Planta Medica · 1982 · 4.8K citations

Natural Sciences, Plant Sciences, Toxicology +12

Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines.

Dominic A. Scudiero, Robert H. Shoemaker, Kenneth D. Paull et al. · PubMed · 1988 · 2.4K citations

Medicine, Oncology, Pharmacology +9

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

Daniel Picot, Patrick J. Loll, R. Michael Garavito · Nature · 1994 · 1.3K citations

Life Sciences, Biochemistry, Molecular Biology +11

6-Alkylamino- and 2,3-Dihydro-3‘-methoxy-2-phenyl-4-quinazolinones and Related Compounds:  Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization

Mann‐Jen Hour, Li‐Jiau Huang, Sheng‐Chu Kuo et al. · Journal of Medicinal Chemistry · 2000 · 407 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Inhibition of Clinically Relevant Mutant Variants of HIV-1 by Quinazolinone Non-Nucleoside Reverse Transcriptase Inhibitors

Jeffrey W. Corbett, Soo S. Ko, James D. Rodgers et al. · Journal of Medicinal Chemistry · 2000 · 301 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16